GENETIC CODE EXPANSION for BIOCATALYSIS and ENZYME ENGINEERING

Our Research

The Marie-Skłodowska-Curie European Doctoral Network BiocatCodeExpander is focused on expanding the diversity of functional groups present in proteins to enhance the fields of biocatalysis and biotechnology by using non-canonical amino acids as building blocks. For this, BiocatCodeExpander brings together experts from synthetic biology, biocatalysis, computational biology, structural biology and organic chemistry to ensure the development of methodologies in a collaborative manner and with a strong participation of the private sector. 

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WORK PACKAGES

BiocatCodeExpander will focus its efforts on three main research objectives:

– Developing better tools enabling methodologies for non-canonical amino acids incorporation to achieve the production efficiency required for successful applications in biocatalysis.

– Diversifying conjugation chemistries and link them to applications for site-specific enzyme immobilization and in vivo probing. 

– Applying non-canonical amino acids as building blocks to improve catalytic properties of enzymes or install new-to-nature activities.

Work Package 1

TOOLS FOR NON-CANONICAL AMINO ACIDS INCORPORATION

 

 

Work Package 2

NOVEL STRATEGIES FOR COUPLING & IMMOBILIZATION

 

 

Work Package 3

ENZYME ENGINEERING WITH NON-CANONICAL AMINO ACIDS

 

 

Work Package 4

TRAINING

 

 

Work Package 5

DISSEMINATION & INNOVATION

 

 

OUR AIM

We aim to develop means that have a positive impact on these areas.